Treatments compared · Oswego, IL
Six wrinkle relaxers, honestly compared
Botox, Dysport, Xeomin, Jeuveau, Daxxify and Letybo are all FDA-approved, all use the same underlying molecule, and all work the same way. The differences are real but smaller than the marketing suggests — here's exactly where they diverge.
Read this before you price-shop
A “unit” means something different in every brand
This is the most useful thing on this page. Units are not a standard measure of strength — each product has its own scale, set by its own manufacturer. Comparing price per unit between two brands tells you nothing at all.
Dysport looks dramatically cheaper per unit and lands in roughly the same place per treatment. A clinic advertising “$8 a unit” may cost you more than one advertising “$14 a unit,” depending entirely on which product is in the syringe.
Ask for the price of treating your area, not the price per unit. That is the only number that compares.
All six, side by side
Tap a priority to highlight the product that leads on it. Scroll the table sideways to see every column.
| BotoxCosmetic | DysportGalderma | XeominMerz | JeuveauEvolus | DaxxifyRevance | LetyboHugel | |
|---|---|---|---|---|---|---|
| Active ingredient | onabotulinumtoxinA | abobotulinumtoxinA | incobotulinumtoxinA | prabotulinumtoxinA | daxibotulinumtoxinA | letibotulinumtoxinA |
| FDA approval (cosmetic) | 2002 | 2009 | 2011 | 2019 | 2022 | Feb 2024 |
| Typical onset | 3–5 days | 2–3 days | 3–5 days | 2–3 days | 3–5 days | 3–5 days |
| Typical duration | 3–4 months | 3–4 months | 3–4 months | 3–4 months | ~6 months in trials | 3–4 months |
| Units vs Botox | 1:1 (the baseline) | ~2.5–3 units per 1 | ≈1:1 | ≈1:1 | Own scale — 40u vs 20u for frown lines | ≈1:1 |
| Formulation | Toxin + accessory proteins | Smaller protein complexes | “Naked” — no accessory proteins | Accessory proteins, closest to Botox | Peptide-stabilised; no human or animal-derived components | Accessory proteins |
| How it spreads | Moderate, predictable | Wider — suits large areas | Precise | Similar to Botox | Similar to Botox | Similar to Botox |
| Also approved for (beyond wrinkles) | Migraine, excess sweating, bladder, muscle spasticity and more | Muscle spasticity, cervical dystonia | Blepharospasm, cervical dystonia, drooling, spasticity | Cosmetic use only | Cervical dystonia | Frown lines (US) |
| Loyalty programme | Allē | ASPIRE | Xperience | Evolus Rewards | Ask at consult | N/A — we do not carry Letybo |
| Known abroad as | Vistabel, Botox Cosmetic | Azzalure, Dysport | Bocouture, Xeomin | Nuceiva, Nabota | Daxxify | Letybo, Botulax |
| Often chosen for | First-timers; the most predictable option | Forehead and other broad areas; speed | Minimal-additive preference; precision work | Cosmetic-only patients; often priced below Botox | Fewer appointments per year | A straightforward, often lower-cost swap for Botox |
| We currently carry | Yes | Yes | Yes | Yes | Yes | Not currently |
Onset and duration are typical ranges, not promises — both vary with dose, treatment area and individual metabolism. Individual results vary.
What each one is actually like
Botox Cosmetic
onabotulinumtoxinA · AbbVie
The original and still the reference point everything else is measured against. Approved for cosmetic use since 2002, with by far the widest range of medical approvals — migraine, excess sweating, bladder conditions and more. Nothing has a longer real-world track record.
Dysport
abobotulinumtoxinA · Galderma
Often described as the fastest to kick in, and it spreads a little more widely through tissue — which is an advantage across a broad forehead and a reason for care near delicate areas. Its units run on a different scale, roughly 2.5 to 3 to one against Botox.
Xeomin
incobotulinumtoxinA · Merz
The "naked" toxin — purified, with the accessory proteins stripped out. The theory is that fewer proteins means less for the immune system to react to, which matters for the small number of long-term patients who find results fading over years. Worth knowing the evidence here is more nuanced than the marketing.
Jeuveau
prabotulinumtoxinA · Evolus
Sometimes marketed as "Newtox." Formulated closest to Botox of any alternative and dosed on essentially the same scale, so it is the most direct swap. It is the only one in the group approved for cosmetic use alone — no medical indications.
Daxxify
daxibotulinumtoxinA · Revance
The long one. Stabilised with a synthetic peptide rather than proteins from human or animal sources, and the trial data showed a median duration around six months — roughly double the rest. It costs more per visit, and you may need fewer visits. Its unit scale is entirely its own.
Letybo
letibotulinumtoxinA · Hugel
The newest arrival, FDA-approved in February 2024, and already the leading toxin in South Korea before it reached the US. Dosed roughly one-to-one with Botox and generally positioned on price. Trial data supports it as a genuine peer; what it lacks is years of US real-world familiarity. We do not currently carry Letybo in Oswego.
The honest summary
For most people, in most areas, all six produce broadly similar results when the dose and the technique are right. The differences that genuinely change your experience are duration (Daxxify), onset and spread (Dysport), and price. Everything else is closer to branding than pharmacology.
Your injector's skill matters more than which vial they open. Placement, dosing and understanding your anatomy account for far more of your result than the brand on the label.
How to actually choose
Switching brands is normal — tell us if you do
There's no medical reason you can't move between products, and plenty of people do. Two things matter when you switch: your injector needs to know what you had, how much, and how you responded, and you shouldn't judge the new one until it's had a full two weeks.
If you've been treated elsewhere, bring the details — the product name and units used, if you have them. Guessing is how people end up over- or under-treated after a switch.
What's coming next
Two products get talked about a lot and neither is available in the US yet. Both were held up in 2026 over manufacturing paperwork rather than anything to do with safety or whether they work.
- Relfydess (relabotulinumtoxinA, Galderma) — the first ready-to-use liquid toxin, so there's no mixing step. Already approved across Europe, Australia and elsewhere, and still working through US review.
- TrenibotE (AbbVie) — a genuinely different animal: a type E toxin rather than type A, reported to start working within about a day and to fade in two to three weeks. Designed as a way to try a wrinkle relaxer without committing to months.
You may also see Myobloc mentioned. It's a type B toxin used for medical conditions such as cervical dystonia and drooling, not for cosmetic treatment.
One thing that matters more than brand
Counterfeit and unapproved toxin is a real problem, and the FDA has warned about harm from fake or mishandled product. Whichever brand you choose, ask where it was purchased, ask to see the vial, and be sceptical of pricing that seems too good to be true.
Every product on this page is prescription-only and should be administered by a qualified, licensed injector following an in-person assessment — in a clinical setting, not at a party or a pop-up. At Hello Gorgeous that means Ryan Kent, FNP-BC on site, under Medical Director Dr. Mukesh Arora, MD.
Not sure which is right for you?
Bring your history and your priorities — speed, duration, budget — and we'll tell you honestly which of the products we carry fits.
Book a free consult(630) 636-6193 · 74 W. Washington Street, Oswego, IL 60543
Common questions
Is one of these actually better than the others?
Not universally. All six are FDA-approved, all use botulinum toxin type A, and all work by the same mechanism. Head-to-head, results are broadly comparable when dosing and technique are appropriate. Where they genuinely differ is duration, onset, spread and price — so “better” depends on which of those matters most to you.
Why is one clinic's price per unit so much lower?
Usually because it's a different product with a different unit scale. Dysport needs roughly two and a half to three times as many units as Botox for the same area, so its per-unit price is naturally much lower while the total is similar. Always compare the cost of treating your area, not the per-unit figure.
Can I switch from Botox to something else?
Yes, and it's common. Your injector will convert the dose rather than matching unit for unit, since the scales differ between products. Tell them exactly what you had before and how you responded, and give the new product a full two weeks before judging it.
Does Daxxify really last six months?
The trial data showed a median of around six months, which is roughly double the others — but a median means half of people got less. Real-world experience varies, and it costs more per treatment. Individual results vary. It's a strong option if you're tired of quarterly appointments, and a poor first choice if you've never had toxin before.
What if my toxin has stopped working?
A few possibilities, and brand is only one. Dose may be too low for your muscle strength, placement may need adjusting, or you may be judging it too early. A small number of long-term patients do develop resistance, which is where Xeomin's protein-free formulation comes into the conversation. Worth assessing properly rather than just switching brands and hoping.
Are the loyalty programmes worth joining?
If you treat regularly, yes — the rebates add up meaningfully over a year. The catch is that each one is tied to a manufacturer, so points follow the brand rather than you. If you expect to switch products often, that's worth factoring in.
Which ones can I get at Hello Gorgeous in Oswego?
We currently carry Botox, Dysport, Xeomin, Jeuveau, and Daxxify. We do not currently carry Letybo. Ryan Kent, FNP-BC is on site six days a week at 74 W. Washington Street, Oswego, IL 60543. Hello Gorgeous Med Spa also has a shorter three-brand walkthrough at Botox vs Dysport vs Jeuveau.
A note on this article. This is general information to help you have a better conversation at your consultation. It isn't medical advice and can't substitute for being assessed in person. All products discussed are prescription medicines; suitability, product choice and dosing are decisions for a qualified clinician who has examined you. Onset, duration and results vary between individuals. Brand names are trademarks of their respective manufacturers, and we have no commercial relationship with any of them beyond purchasing product. Information verified August 2026. Last reviewed by Ryan Kent, FNP-BC, with physician oversight by Dr. Mukesh Arora, MD.