Ozempic and Zepbound have transformed weight loss. But what comes next? Retatrutide — a "triple agonist" that targets three hunger-regulating hormones — is in late-stage clinical trials and could be the next generation of weight loss medication.
Here's what we know about Retatrutide and what it means for your weight loss journey.
What Is Retatrutide?
Retatrutide is an investigational medication by Eli Lilly that mimics three hormones:
- •1. GLP-1 (glucagon-like peptide-1) — reduces appetite, slows gastric emptying
- •2. GIP (glucose-dependent insulinotropic polypeptide) — metabolic effects, appetite regulation
- •3. Glucagon — energy expenditure, fat metabolism
Semaglutide (Ozempic/Wegovy) targets one. Tirzepatide (Mounjaro/Zepbound) targets two. Retatrutide targets three — hence "triple agonist."
Clinical Results So Far
Phase 2 trials: Up to 24.2% body weight loss at the highest dose — the highest ever recorded for a GLP-1 class medication in clinical trials.
Phase 3 (TRIUMPH-4, Dec 2025): Participants with obesity and knee osteoarthritis achieved up to 28.7% body weight loss (average 71.2 lbs) and 75.8% reduction in knee pain at 68 weeks.
These results suggest Retatrutide could produce even greater weight loss than Tirzepatide or Semaglutide — when it becomes available.
Current Status: Not Yet FDA Approved
As of 2026, Retatrutide is not yet FDA-approved. It remains in Phase 3 clinical trials. Expected timeline:
- •NDA submission: Late 2025 – Q1 2026
- •FDA approval: Projected 2026–2027
Retatrutide is not available through pharmacies or prescriptions outside of clinical trials at this time.
Retatrutide vs Ozempic vs Zepbound
| Medication | Hormone Targets | Avg. Weight Loss (Trials) | FDA Status |
|---|---|---|---|
| Semaglutide (Ozempic/Wegovy) | GLP-1 | ~15% | Approved |
| Tirzepatide (Mounjaro/Zepbound) | GLP-1 + GIP | ~20–22% | Approved |
| Retatrutide | GLP-1 + GIP + Glucagon | ~24–28% (trials) | In development |
What to Do Now
If you're ready to start weight loss today, Semaglutide and Tirzepatide are available now at Hello Gorgeous. Our NP can prescribe and supervise your GLP-1 program with same-day consultations.
When Retatrutide receives FDA approval, we'll evaluate adding it to our weight loss program — as we do with all new medications — based on safety, efficacy, and availability.
Don't wait: The best time to start is now. You can always switch or add medications later if Retatrutide becomes available and is right for you.
Why Hello Gorgeous for Weight Loss?
- •Semaglutide and Tirzepatide available today — Same-day prescriptions, NP supervision
- •Loose skin solution — Morpheus8 Burst, Quantum RF, Solaria CO₂ for post-weight loss tightening
- •Serving Oswego, Naperville, Aurora, Plainfield, Yorkville, Montgomery
Book Your Weight Loss Consultation
📞 630-636-6193
🌐 hellogorgeousmedspa.com/book
📍 74 W Washington Street, Oswego, IL 60543
Start your weight loss journey today. We'll keep you informed about new options as they become available.